Adam Mol
Adam is the Marie Skłodowska-Curie TRAIN@Ed fellow developing novel aptamer-based tools for drugging the 'undruggable' cancer targets.
Data-Driven Innovation Expert Profile
Using Biology to Treat Biology - Public Engagement Video
Background
He completed his doctoral studies at Synthetic Genetic Circuits group headed by Prof. Beatrix Suess in Technical University of Darmstadt in Germany, as part of the Marie Skłodowska-Curie ITN MetaRNA network spanning the interface between RNA biology and metabolism at the single cell level. Adam has been investigating research related to the conditional control of alternative splicing and translation with synthetic riboswitches in human cells. Alternative splicing of pre-mRNA in mammals is one of the important cellular processes and disruption of the splicing machinery lead to genetic disease and cancer. Thus, reprogramming of aberrant splicing could provide novel approaches to the development of molecular therapy.
Research
Adam is developing and applying the tools and methods of mammalian synthetic biology to unmet needs in basic biology and medicine. Finely tunable mammalian gene expression control systems could precisely relate protein levels to function, or could enable novel approaches to gene therapy. To build more robust genetic systems, Adam will make an effort to incorporate greater complexity into the design of synthetic circuits, such as developing more effective feedback control for therapeutic applications.
Publications
Adam have been involved with a Science and Art Biopolis – Tales of Urban Biology project that has resulted in a book of stories.
Mol, A. A., M. Vogel and B. Suess. 2021. Inducible nuclear import by TetR aptamer-controlled 3' splice site selection. RNA , 27(2):234-241. doi: 10.1261/rna.077453.120. PMID: 33148600
Mol, A. A., F. Groher, B. Schreiber, C. Rühmkorff and B. Suess. 2019. Robust gene expression control in human cells with a novel universal TetR aptamer splicing module. Nucleic Acids Research, 18;47(20):e132. doi: 10.1093/nar/gkz753. PMID: 31504742
Mol, A. A. and M. Stolarek. 2011. Induced damages of DNA by mutagens and the mechanisms of their formation. Advances in Cell Biology 38: 491-505
Contact
Phone No: 0131 650 5416
Email: adam.mol@ed.ac.uk
Twitter: @adamm0l
