Dr Rebecca Holmes

Rebecca Holmes


Rebecca completed her PhD in the laboratory of Michael Malim at King’s College London, where she worked on unraveling the mechanism by which APOBEC proteins inhibit viral replication. For her postdoctoral work, Rebecca was awarded a Sir Henry Wellcome Postdoctoral Fellowship for research focused on dissecting mechanisms regulating gene expression in S.cerevisiae. This project was carried out in the laboratories of Christine Guthrie (University of California, San Francisco) and David Tollervey (University of Edinburgh).


Rebecca is working on a collaborative project with Ingenza Ltd, using CRISPR/Cas9 to generate stress tolerant yeast strains with applications in the bioethanol industry.

Holmes RK, Tuck AC, Zhu C, Dunn-Davies HR, Kudla G, Clauder-Munster S, Granneman S, Steinmetz LM, Guthrie C, Tollervey D (2015). Loss of the yeast SR protein Npl3 alters gene expression due to transcription readthrough. PLoS Genetics. 2015 Dec 22; 11(12):e1005735

Fehrholz M, Kendl S, Prifert C, Weissbrich B, Lemon K, Rennick L, Duprex PW, Rima BK, Koning FA, Holmes RK, Malim MH, Schneider-Schaulies J (2011). The innate antiviral factors APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses. Journal of General Virology. 2012 Mar;93(Pt3):565-76.

Gallois-Montbrun S, Holmes RK, Swanson CM, Hireia FO, Byers HL, Ward MA and Malim MH (2008). Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins. Journal of Virology. 2008 Jun;82(11):5636-42.

Holmes RK, Malim MH, and Bishop KN (2007).  APOBEC-mediated viral restriction: not simply editing?  Trends in Biochemical Sciences. Mar;32(3):118-28.

Holmes RK, Koning FA, Bishop KN and Malim MH (2007). APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation: comparisons with APOBEC3G.  Journal of Biological Chemistry.  Jan 26; 282(4):2587-95.

Bishop KN, Holmes RK, and Malim MH (2006).  Antiviral potency of APOBEC proteins does not correlate with cytidine deamination.  Journal of Virology.  Sep; 80(17):8450-8458.

Newman ENC, Holmes RK, Craig HM, Klein KC, Lingappa JR, Malim MH, and Sheehy AM (2005).  Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity.  Current Biology.  Jan 26; 15(2):166-170.

Bishop KN, Holmes RK, Sheehy AM, Davidson NO, Cho S-J, and Malim MH (2004).  Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins.  Current Biology.  Aug 10; 14(15):1392-1396.

Bishop KN, Holmes RK, Sheehy AM, and Malim MH (2004).  APOBEC-Mediated Editing of Viral RNA.  Science. Jul 30; 305(5684):645.

Phone No: 0131 650 54 16