Dr Adam Mol

Adam Mol

Background


Adam completed his doctoral studies under the supervision of Prof. Beatrix Suess in Darmstadt, Germany, as part of the Marie Skłodowska Curie ITN MetaRNA network (http://metarna.eu/). He has been investigating research related to the conditional control of alternative splicing and translation with synthetic riboswitches in human cells. Alternative splicing of pre-mRNA in mammals is one of the important cellular processes and disruption of the splicing machinery lead to genetic disease and cancer. Reprogramming of aberrant splicing could provide novel approaches to the development of molecular therapy.

Research


Adam is a postdoctoral research associate currently developing and applying the tools and methods of mammalian synthetic biology to unmet needs in basic biology and biomedicine. Finely tunable mammalian gene expression control systems could precisely relate protein levels to function, or could enable novel approaches to gene therapy. To build more robust genetic systems, Adam will make an effort to incorporate greater complexity into the design of synthetic circuits, such as developing more effective feedback control for therapeutic applications.

Publications


Mol, A. A., Groher F, Schreiber B, Suess B. Robust gene expression control in human cells with a novel universal TetR aptamer splicing module. in revision.

Mol, A. A. and Suess B. Control of nuclear import using a synthetic RNA aptamer. in revision.

Mol, A. A. and M. Stolarek. 2011. Induced damages of DNA by mutagens and the mechanisms of their formation. Advances in Cell Biology 38: 491-505.

Contact


Phone No: 0131 650 54 16

Email: amol@exseed.ed.ac.uk